This document is endorsed by more than 35 organizations involved in humanitarian assistance. It provides essential guidance for multi-sector responses to protect and improve people’s mental health and psychosocial well-being in the midst of an emergency, offering an overall framework for MHPSS integration, activities and services in humanitarian settings across different sectors such as health, protection and education. The guidelines call for Mental Health and Psychosocial Support services and activities to be implemented in a way that is coordinated, evidence-based, participatory, integrated, avoids harm and builds on existing resources and capacities, and to organizing a multi-layered system of complementary supports that meets the needs of different groups.